Hemoglobin A1c Testing to know your AGE (AGE = advanced glycation end-products)

June 25, 2013

The hemoglobin A1c test is a well known tool for following long-term glucose control in patients with diabetes. However, the same blood test also helps identify age-accelerating glycation reactions in the body.

New studies reveal that all of us may suffer from the damage inflicted by advanced glycation end-products (AGEs), which are formed when sugars bind with proteins or amino acids in the body.  AGEs cause damage by causing cross-linking that causes intracellular damage and apoptosis. Recent research indicates that these damaging end products play a role in heart disease, cancer, neurodegeneration (dementia), cataracts  and the aging process itself.   Monitoring hemoglobin A1c levels is essential for all adults who wish to identify excess glycation processes in their bodies and take measures to control and minimize glycation-induced damage.

Research suggests that a hemoglobin A1c level of less than 5% is ideal.  Surprisingly, glucose is only part of what increases the A1c.   The A1c goes for two reasons;

1.    We eat foods that raise our glucose.  Sugary, starchy food cause our glucose to increase and this causes glycation of our bodies proteins.
2.    We eat AGE rich foods.  The ingestion of dietary AGE’s from foods cooked at high temperatures.

1.    Follow the optimal eating program.  Avoid processed foods, sugar, fructose, grains – especially wheat (even whole grain). Animal-derived foods that are high in fat and protein are generally AGE-rich and prone to new AGE formation during cooking. In contrast vegetables and fruits contain relatively few AGEs, even after cooking.
2.    Cook Smart: Steam, Stew,  Boil.  AGEs are significantly reduced by cooking with moist heat, using shorter cooking times, cooking at lower temperatures, and by use of acidic ingredients such as lemon juice or vinegar.  low-AGE– generating cooking methods such as poaching, steaming, stewing, and boiling.  For example, the high AGE content of broiled chicken (5,828 kU/100 g) and broiled beef (5,963 kU/100 g) can be significantly reduced(1,124 kU/100 g and 2,230 kU/100 g, respectively) when the same piece of meat is either boiled or stewed. The use of acidic marinades, such as lemon juice and vinegar,before cooking can also be encouraged to limit AGE generation. These culinary techniques have long been featured in Mediterranean, Asian, and other cuisines throughout the world to create palatable, easily prepared dishes.
3.    Exercise regularly.
4.    Hormonal balance: thyroid, DHEA, testosterone in men, progesterone in women.
5.    Supplements to lower AGE include: Cinnamon, garlic, psyllium, chromium 400-1000 mcg/day, alpha lipoic acid 300-600 mg/day, fish oil – 1 teaspoon or 4 capsules, carnosine, and benfotiamine Vitamin_C,  Vitamin B6,  L-taurine.  Resveratrol helps protect against AGE damage.

1. O’Sullivan JB, Mahan CM. Mortality related to diabetes and blood glucose levels in a community study. Am J Epidemiol. 1982 Oct;116(4):678-84.

2. Asadollahi K, Beeching N, Gill G. Hyperglycaemia and mortality. J R Soc Med. 2007 Nov;100(11):503-7.

3. Palumbo F, Bianchi C, Miccoli R, Del PS. Hyperglycaemia and cardiovascular risk. Acta Diabetol. 2003 Dec;40(Suppl 2):S362-9.

4. DeGroot J. The AGE of the matrix: chemistry, consequence and cure. Curr Opin Pharmacol. 2004 Jun;4(3):301-5.

5. Available at: http://www.nlm.nih.gov/medlineplus/ency/article/003640.htm. Accessed January 16, 2008.

6. Dailey G. Assessing glycemic control with self-monitoring of blood glucose and hemoglobin A(1c) measurements. Mayo Clin Proc. 2007 Feb;82(2):229-35.

7. Osterman-Golkar SM, Vesper HW. Assessment of the relationship between glucose and A1c using kinetic modeling. J Diabetes Complications. 2006 Sep;20(5):285-94.

8. Robert L, Robert AM, Fulop T. Rapid increase in human life expectancy: will it soon be limited by the aging of elastin? Biogerontology. 2008;Jan 4.

9. Vasdev S, Gill V, Singal P. Role of advanced glycation end products in hypertension and atherosclerosis: therapeutic implications. Cell Biochem Biophys. 2007;49(1):48-63.

10. Whitmer RA. Type 2 diabetes and risk of cognitive impairment and dementia. Curr Neurol Neurosci Rep. 2007 Sep;7(5):373-80.

11. Yamagishi S, Adachi H, Takeuchi M, et al. Serum level of advanced glycation end-products (AGEs) is an independent determinant of plasminogen activator inhibitor-1 (PAI-1) in nondiabetic general population. Horm Metab Res. 2007 Nov;39(11):845-8.

12. Nawale RB, Mourya VK, Bhise SB. Non-enzymatic glycation of proteins: a cause for complications in diabetes. Indian J Biochem Biophys. 2006 Dec;43(6):337-44.

13. Landgraf R. HbA1c—the gold standard in the assessment of diabetes treatment? Dtsch Med Wochenschr. 2006 Dec;131(Suppl 8):S243-6.

14. Takeuchi M, Yamagishi S. TAGE (toxic AGEs) hypothesis in various chronic diseases. Med Hypotheses. 2004;63(3):449-52.

15. Available at: http://labtestsonline.org/understanding/analytes/a1c/test.html. Accessed January 18, 2008.

16. Hudson PR, Child DF, Jones H, Williams CP. Differences in rates of glycation (glycation index) may significantly affect individual HbA1c results in type 1 diabetes. Ann Clin Biochem. 1999 Jul;36(Pt 4):451-9.

17. Geberhiwot T, Haddon A, Labib M. HbA1c predicts the likelihood of having impaired glucose tolerance in high-risk patients with normal fasting plasma glucose. Ann Clin Biochem. 2005 May;42(Pt 3):193-5.

18. Harper JM, Durkee SJ, Smith-Wheelock M, Miller RA. Hyperglycemia, impaired glucose tolerance and elevated glycated hemoglobin levels in a long-lived mouse stock. Exp Gerontol. 2005 Apr;40(4):303-14.

19. Kalantar-Zadeh K, Kopple JD, Regidor DL, et al. A1C and survival in maintenance hemodialysis patients. Diabetes Care. 2007 May;30(5):1049-55.

20. American Diabetes Association. Standards of medical care for patients with diabetes mellitus. Diabetes Care. 2003 Jan;26 Suppl 1:S33-50.

21. Baron P. The ten most important blood tests. Life Extension. 2006 May;12(5):42-51.

22. Yudkin JS, Forrest RD, Jackson CA, Ryle AJ, Davie S, Gould BJ. Unexplained variability of glycated haemoglobin in non-diabetic subjects not related to glycaemia. Diabetologia. 1990 Apr;33(4):208-15. 

Written By: Steven F. Hotze, M.D.

Steven F. Hotze, M.D., is the founder and CEO of the Hotze Health & Wellness Center, Hotze Vitamins and Physicians Preference Pharmacy International, LLC.

 

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