Progestins induce transcriptional activation of signal transducer and activator of transcription 3 (

June 30, 2011

These results demonstrate that progestins are able to induce Stat3 transcriptional activation, which is in turn an obligatory requirement for progestin stimulation of both in vitro and in vivo breast cancer growth.
Proietti C, et al. (June 2005). Progestins induce transcriptional activation of signal transducer and activator of transcription 3 (Stat3) via a Jak- and Src-dependent mechanism in breast cancer cells. Mol Cell Biol. 2005 Jun;25(12):4826-40.

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