The Blood Sugar–Brain Connection

January 26, 2026

When Brain Fog Is a Metabolic Signal 

Have you ever walked into a room and forgotten why you went in there in the first place? Lost your train of thought mid-sentence? Know what you want to say, but the words are just not coming to you? Felt mentally sharp in the morning but foggy and unfocused by midafternoon? 

Many people assume this is just stress, aging, or poor sleep. However, one of the most overlooked contributors to cognitive clarity is blood sugar. 

Blood sugar swings do not just affect weight or energy levels. They directly influence memory, focus, mood, and long-term brain health.¹ At Hotze Health & Wellness Center, we often see guests (we call our patients guests) whose cognitive symptoms are simply due to an underlying metabolic imbalance. 

Brain fog is not a character flaw. It is not inevitable. It is often a signal. 

What Makes Hotze Health & Wellness Center Different 

At Hotze Health & Wellness Center, we do not separate brain health from the rest of the body. We also do not wait for a disease to appear before taking action. We listen to your clinical symptoms in addition to comprehensive blood work results, and we treat the entire body. 

For more than 36 years, we have helped guests who were told their symptoms were “normal,” their labs were “fine,” or that cognitive changes were “simply part of getting older and you just need to live with it.” We believe those answers fall short and, in most cases, are not true. 

What makes our approach different is simple. We focus on prevention, wellness, and healthspan, not just longevity (longevity is living longer; healthspan is living longer AND living healthier). We also do not focus on singular symptoms or masking symptoms. Our approach is to treat the entire body, thereby getting to the root cause.  

Instead of asking only, “What medication treats this symptom?” we ask: 
Why is this happening, and how can we support the body before decline accelerates? 

Our care is built on several core principles: 

  • We look for root causes, not isolated symptoms 
  • We prioritize healthspan, not just lifespan (longevity) 
  • We view blood sugar regulation as foundational to brain health and aging (and much more) 
  • We use comprehensive, personalized testing to identify early metabolic stress and cognitive decline 
  • We support guests at every stage of life within our alternative and integrative medical practice (children to mature adults).  Did you know that cognitive decline can begin as early as age 30? 

This perspective shapes how we approach cognitive concerns from the very beginning. 

Why Blood Sugar Matters to the Brain 

The brain is one of the most energy-demanding organs in the body. Although it accounts for only about 2 percent of body weight, it uses roughly 20 percent of the body’s glucose supply.² 

That means the brain depends on a steady, reliable fuel source. 

When blood sugar is stable, neurons function efficiently. When blood sugar rises too high, drops too low, or swings rapidly, brain cells experience metabolic stress. Over time, this can affect attention, memory, processing speed, and mental stamina.³ 

This is why blood sugar regulation is not just a metabolic issue. It is a brain health and healthspan (longevity) issue. 

Insulin, Neurons, and Mental Clarity 

Glucose cannot enter most cells without insulin, including brain cells. 

Insulin acts as a signaling molecule that helps neurons absorb and use glucose for energy. When insulin signaling works well, brain cells stay fueled and responsive. When insulin signaling becomes impaired, neurons struggle to access energy even when glucose is available.⁴ 

This condition is known as insulin resistance, and it not only affects muscles or the liver. It can also affect the brain. 

Research shows that impaired insulin signaling in the brain is associated with: 

  • Reduced glucose uptake 
  • Slower cognitive processing 
  • Challenges with learning and memory⁵ 

Some researchers refer to this phenomenon as Type 3 diabetes. While not a formal diagnosis, it highlights the growing scientific understanding of the blood sugar and brain health connection.⁶ 

Symptoms That Often Point to Blood Sugar Dysregulation 

Many people are surprised to learn that cognitive symptoms can be tied to blood sugar instability. 

Common signs include: 

  • Brain fog or mental cloudiness 
  • Difficulty concentrating 
  • Poor short-term memory 
  • Irritability or mood swings 
  • Fatigue after meals 
  • Cravings for sugar or refined carbohydrates
  • Afternoon energy crashes 

When these symptoms appear alongside weight gain, sleep disruption, hormone imbalance, or chronic stress, they often reflect a metabolic pattern, not an isolated brain issue.¹³ 

Why “Normal” Labs Often Miss the Problem 

Standard lab work frequently includes fasting glucose alone. While helpful, fasting glucose does not capture the full picture. 

Blood sugar dysregulation and insulin resistance can exist for years before fasting glucose becomes abnormal.⁷ During this time, metabolic stress may already be affecting the brain. 

This is why many guests are told everything looks normal while they continue to struggle with focus, memory, or mental fatigue. 

Blood Sugar, Brain Health, and Healthspan 

Brain health is not only about how clearly you think today. It is also about how well your brain functions decades from now. Remember, longevity is living longer; Healthspan is living longer AND living healthier.  We stress this at Hotze Health & Wellness Center because our population is, in fact, living longer. However, how many elderly individuals do you know who are dissatisfied with their quality of life?  How many friends or loved ones that you know (or maybe that someone is you) need to care for their elderly parents who are dealing with significant cognitive decline, dementia, or Alzheimer’s?  Longevity is not enough. Healthspan (living longer and living healthier) should be the goal.   

At Hotze Health & Wellness Center, we focus on healthspan, the years of life spent in good physical, cognitive, and emotional health. The ultimate goal is living longer with clarity, energy, and independence. 

Chronic blood sugar dysregulation and insulin resistance are associated with accelerated cellular aging, increased inflammation, and impaired mitochondrial efficiency.⁸ ⁹ These processes influence how efficiently brain cells produce energy and respond to stress over time. 

From a healthspan perspective, stable blood sugar supports: 

  • Healthier mitochondrial function 
  • More efficient cellular energy production 
  • Reduced inflammatory signaling 
  • Greater cognitive resilience with age 

This is why metabolic health sits at the foundation of our healthspan (longevity) philosophy. 

Comprehensive Testing as a Foundation of Longevity (Healthspan) Care 

A key part of our longevity-focused approach is comprehensive, personalized testing. 

As part of our Longevity Wellness Programs, our providers recommend advanced bloodwork and laboratory testing tailored to each guest’s unique goals, symptoms, and stage of life. This testing helps us: 

  • Identify early blood sugar and insulin signaling imbalances 
  • Assess inflammatory and metabolic patterns 
  • Evaluate hormone balance and nutrient status 
  • Detect cellular stress that may affect brain health over time 

Rather than waiting for disease to appear, comprehensive testing allows us to take a proactive, prevention-focused approach to cognitive health and aging. 

Nutrition, Movement, and Metabolic Support for the Brain 

Supporting blood sugar stability supports both short-term cognition and long-term brain health. 

Evidence-based strategies include: 

  • Balanced meals with protein, fiber, and healthy fats 
  • Reducing refined carbohydrates and added sugars 
  • Consistent meal timing 
  • Regular physical activity to improve insulin sensitivity¹⁰ 

Even moderate movement has been shown to enhance insulin signaling and support cognitive performance by improving blood flow and cellular energy efficiency in the brain.¹¹ 

These habits are not about restriction. They are about creating an internal environment that supports clarity today and resilience tomorrow. 

A Root-Cause Approach to Cognitive Health 

Many guests come to Hotze Health & Wellness Center after being told nothing is wrong, despite persistent brain fog or cognitive changes. They also come to us because they do not want to be placed on numerous unproven pharmaceutical drugs that are being pushed on individuals who feel they have no hope or no other alternative.  

By looking at blood sugar regulation, insulin signaling, hormone balance, inflammation, and nutrient status together, we seek to understand why the brain is struggling. This approach allows us to support not only symptom relief, but also long-term cognitive vitality and quality of life.¹² We believe that cognitive decline, at most stages, CAN be treated effectively. 

Exploring Your Next Step 

Take the Symptom Checker 

Our symptom checker helps identify patterns related to blood sugar imbalance, hormone disruption, adrenal stress, and more. Click HERE to take our symptom checker. 

More Importantly, Schedule a Complimentary Wellness Consultation 

If you, a friend, or loved one is ready to explore a new path to wellness, click HERE to schedule a complimentary phone consultation with one of our Wellness Consultants. Our consultations are always free. It’s a pressure-free conversation where you can ask questions, share your concerns, and discover whether our natural, root-cause approach is the right fit for you. It would be our privilege to serve you. 

Protecting Brain Health for the Long Run 

Brain fog, memory lapses, and mental fatigue are not random. They are often early metabolic signals. When it comes to cognitive decline, while we believe treatment and even reversal of symptoms can effectively occur at any stage, it is ALWAYS BEST TO BEGIN AT THE EARLIEST ONSET. Prevention is even better. If you know of or suspect a family history of cognitive decline, then you need to be your own self-advocate. Lifestyle changes and partnering with experts in alternative and integrative approaches are your best medicine.  

By addressing blood sugar regulation and insulin sensitivity, you are not only supporting how you feel today. You are investing in your brain health, longevity, and, more importantly, healthspan for years to come.  

Let’s explore your next step together. Call today for your Complimentary Wellness Consultation at 281-698-8698 or Click HERE to schedule now, at your convenience.  

References 

  1. Craft, Suzanne. Insulin Resistance and Alzheimer’s Disease Pathogenesis. Diabetes, vol. 61, no. 6, 2012, pp. 1354–1360. 
  2. Raichle, Marcus E., and Gusnard, Debra A. Appraising the Brain’s Energy Budget. Proceedings of the National Academy of Sciences, 2002. https://www.pnas.org/doi/10.1073/pnas.172399499 
  3. Kerti, L., et al. Higher Glucose Levels Associated With Lower Memory and Reduced Hippocampal Microstructure. Neurology, 2013. 
  4. Arnold, Sarah E., et al. Brain Insulin Resistance in Type 2 Diabetes and Alzheimer Disease. Nature Reviews Neurology, 2018.
  5. Talbot, K., et al. Demonstrated Brain Insulin Resistance in Alzheimer’s Disease. Journal of Clinical Investigation, 2012. https://www.jci.org/articles/view/59903 
  6. de la Monte, Suzanne M. Type 3 Diabetes Is Sporadic Alzheimer’s Disease. Journal of Diabetes Science and Technology, 2008. https://pubmed.ncbi.nlm.nih.gov/19885299/ 
  7. Tabák, Adam G., et al. Prediabetes: A High-Risk State for Diabetes Development. The Lancet, 2012. https://pubmed.ncbi.nlm.nih.gov/22683128/ 
  8. López-Otín, Carlos, et al. The Hallmarks of Aging. Cell, 2013. https://pubmed.ncbi.nlm.nih.gov/23746838/ 
  9. Mattson, Mark P., et al. Metabolic Regulation and Brain Aging. Physiological Reviews, 2018. 
  10. Ludwig, David S. The Glycemic Index: Physiological Mechanisms Relating to Obesity, Diabetes, and Cardiovascular Disease. JAMA, 2002. 
  11. Erickson, Kirk I., et al. Exercise Training Increases Size of Hippocampus and Improves Memory. Proceedings of the National Academy of Sciences, 2011. https://www.pnas.org/doi/10.1073/pnas.1015950108 
  12. Petersen, Ronald C. Mild Cognitive Impairment. New England Journal of Medicine, 2011. https://www.nejm.org/doi/full/10.1056/NEJMcp0910237 
  13. Sripetchwandee, J., et al. Insulin Resistance and Cognitive Impairment. Neuroscience, 2014. 

          Written By: Steven F. Hotze, M.D.

          Steven F. Hotze, M.D., is the founder and CEO of the Hotze Health & Wellness Center, Hotze Vitamins and Physicians Preference Pharmacy International, LLC.

           

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