Hemoglobin A1c Testing to know your AGE (AGE = advanced glycation end-products)

June 25, 2013

The hemoglobin A1c test is a well known tool for following long-term glucose control in patients with diabetes. However, the same blood test also helps identify age-accelerating glycation reactions in the body.

New studies reveal that all of us may suffer from the damage inflicted by advanced glycation end-products (AGEs), which are formed when sugars bind with proteins or amino acids in the body.  AGEs cause damage by causing cross-linking that causes intracellular damage and apoptosis. Recent research indicates that these damaging end products play a role in heart disease, cancer, neurodegeneration (dementia), cataracts  and the aging process itself.   Monitoring hemoglobin A1c levels is essential for all adults who wish to identify excess glycation processes in their bodies and take measures to control and minimize glycation-induced damage.

Research suggests that a hemoglobin A1c level of less than 5% is ideal.  Surprisingly, glucose is only part of what increases the A1c.   The A1c goes for two reasons;

1.    We eat foods that raise our glucose.  Sugary, starchy food cause our glucose to increase and this causes glycation of our bodies proteins.
2.    We eat AGE rich foods.  The ingestion of dietary AGE’s from foods cooked at high temperatures.

1.    Follow the optimal eating program.  Avoid processed foods, sugar, fructose, grains – especially wheat (even whole grain). Animal-derived foods that are high in fat and protein are generally AGE-rich and prone to new AGE formation during cooking. In contrast vegetables and fruits contain relatively few AGEs, even after cooking.
2.    Cook Smart: Steam, Stew,  Boil.  AGEs are significantly reduced by cooking with moist heat, using shorter cooking times, cooking at lower temperatures, and by use of acidic ingredients such as lemon juice or vinegar.  low-AGE– generating cooking methods such as poaching, steaming, stewing, and boiling.  For example, the high AGE content of broiled chicken (5,828 kU/100 g) and broiled beef (5,963 kU/100 g) can be significantly reduced(1,124 kU/100 g and 2,230 kU/100 g, respectively) when the same piece of meat is either boiled or stewed. The use of acidic marinades, such as lemon juice and vinegar,before cooking can also be encouraged to limit AGE generation. These culinary techniques have long been featured in Mediterranean, Asian, and other cuisines throughout the world to create palatable, easily prepared dishes.
3.    Exercise regularly.
4.    Hormonal balance: thyroid, DHEA, testosterone in men, progesterone in women.
5.    Supplements to lower AGE include: Cinnamon, garlic, psyllium, chromium 400-1000 mcg/day, alpha lipoic acid 300-600 mg/day, fish oil – 1 teaspoon or 4 capsules, carnosine, and benfotiamine Vitamin_C,  Vitamin B6,  L-taurine.  Resveratrol helps protect against AGE damage.

1. O’Sullivan JB, Mahan CM. Mortality related to diabetes and blood glucose levels in a community study. Am J Epidemiol. 1982 Oct;116(4):678-84.

2. Asadollahi K, Beeching N, Gill G. Hyperglycaemia and mortality. J R Soc Med. 2007 Nov;100(11):503-7.

3. Palumbo F, Bianchi C, Miccoli R, Del PS. Hyperglycaemia and cardiovascular risk. Acta Diabetol. 2003 Dec;40(Suppl 2):S362-9.

4. DeGroot J. The AGE of the matrix: chemistry, consequence and cure. Curr Opin Pharmacol. 2004 Jun;4(3):301-5.

5. Available at: http://www.nlm.nih.gov/medlineplus/ency/article/003640.htm. Accessed January 16, 2008.

6. Dailey G. Assessing glycemic control with self-monitoring of blood glucose and hemoglobin A(1c) measurements. Mayo Clin Proc. 2007 Feb;82(2):229-35.

7. Osterman-Golkar SM, Vesper HW. Assessment of the relationship between glucose and A1c using kinetic modeling. J Diabetes Complications. 2006 Sep;20(5):285-94.

8. Robert L, Robert AM, Fulop T. Rapid increase in human life expectancy: will it soon be limited by the aging of elastin? Biogerontology. 2008;Jan 4.

9. Vasdev S, Gill V, Singal P. Role of advanced glycation end products in hypertension and atherosclerosis: therapeutic implications. Cell Biochem Biophys. 2007;49(1):48-63.

10. Whitmer RA. Type 2 diabetes and risk of cognitive impairment and dementia. Curr Neurol Neurosci Rep. 2007 Sep;7(5):373-80.

11. Yamagishi S, Adachi H, Takeuchi M, et al. Serum level of advanced glycation end-products (AGEs) is an independent determinant of plasminogen activator inhibitor-1 (PAI-1) in nondiabetic general population. Horm Metab Res. 2007 Nov;39(11):845-8.

12. Nawale RB, Mourya VK, Bhise SB. Non-enzymatic glycation of proteins: a cause for complications in diabetes. Indian J Biochem Biophys. 2006 Dec;43(6):337-44.

13. Landgraf R. HbA1c—the gold standard in the assessment of diabetes treatment? Dtsch Med Wochenschr. 2006 Dec;131(Suppl 8):S243-6.

14. Takeuchi M, Yamagishi S. TAGE (toxic AGEs) hypothesis in various chronic diseases. Med Hypotheses. 2004;63(3):449-52.

15. Available at: http://labtestsonline.org/understanding/analytes/a1c/test.html. Accessed January 18, 2008.

16. Hudson PR, Child DF, Jones H, Williams CP. Differences in rates of glycation (glycation index) may significantly affect individual HbA1c results in type 1 diabetes. Ann Clin Biochem. 1999 Jul;36(Pt 4):451-9.

17. Geberhiwot T, Haddon A, Labib M. HbA1c predicts the likelihood of having impaired glucose tolerance in high-risk patients with normal fasting plasma glucose. Ann Clin Biochem. 2005 May;42(Pt 3):193-5.

18. Harper JM, Durkee SJ, Smith-Wheelock M, Miller RA. Hyperglycemia, impaired glucose tolerance and elevated glycated hemoglobin levels in a long-lived mouse stock. Exp Gerontol. 2005 Apr;40(4):303-14.

19. Kalantar-Zadeh K, Kopple JD, Regidor DL, et al. A1C and survival in maintenance hemodialysis patients. Diabetes Care. 2007 May;30(5):1049-55.

20. American Diabetes Association. Standards of medical care for patients with diabetes mellitus. Diabetes Care. 2003 Jan;26 Suppl 1:S33-50.

21. Baron P. The ten most important blood tests. Life Extension. 2006 May;12(5):42-51.

22. Yudkin JS, Forrest RD, Jackson CA, Ryle AJ, Davie S, Gould BJ. Unexplained variability of glycated haemoglobin in non-diabetic subjects not related to glycaemia. Diabetologia. 1990 Apr;33(4):208-15. 

Written By: Steven F. Hotze, M.D.

Steven F. Hotze, M.D., is the founder and CEO of the Hotze Health & Wellness Center, Hotze Vitamins and Physicians Preference Pharmacy International, LLC.

 

Leave a Reply

Your email address will not be published. Required fields are marked *

AboutHotze Health & Wellness Center

Since 1989, Hotze Health & Wellness Center has helped over 33,000 patients get their lives back using bioidentical hormones that restore hormones to optimal levels, strengthen immune systems, and increase energy levels. Our treatment regimen addresses the root cause of hypothyroidism, adrenal fatigue, menopause, perimenopause, low testosterone, allergies, and candida.

Led by best-selling author, radio host and leading natural health expert, Steven F. Hotze, M.D., our medical team has over 100 years’ combined medical experience backed by a staff of nearly 100 caring professionals who provide an environment of hope and extraordinary hospitality for each of our patients, who we call our guests. It is our deepest desire to help you obtain and maintain health and wellness naturally so that you may enjoy a better quality of life, pure and simple.

 

What I BelieveBY DR. STEVEN HOTZE

Do you want to live a healthy, happy, purpose-driven life? Do you want to restore your health so that your loss of energy, weight gain, joint pain, depression and lack of drive or motivation won’t hold you back from achieving your personal and professional goals?

Dr. Steven Hotze wants that for you, too. In fact, in his powerful and passionate video entitled, “What I Believe”, Dr. Hotze shares how his Christian worldview and pivotal experiences have ignited a deep desire to offer the message of hope and optimal health to all who need to hear it.


Follow Us
#hotzehealth

As seen on:

  • ABC
  • Fow News Channel
  • NBC
  • CNN
  • The Biography Channel
  • Bloomberg Businessweek
  • The Early Show
  • Good Morning Texas
  • Great Day Houston

Our Doctors

At Hotze Health & Wellness Center, our doctors are changing the way women and men are treated through the use of bioidentical hormones. Our natural treatments have helped over 33,000 individuals with hypothyroidism, adrenal fatigue, menopause, perimenopause, low testosterone, allergies, candida, detoxification and nutritional deficiencies.

Meet our doctors

Guest Testimonials

Peggy W.

"After just 3 weeks into the program, my joint pain was gone, climbing stairs became easy, my energy level increased from 2 to a 9 (out of 10) and I lost almost 30 pounds! ”

Read More guest testimonials
Pam White
Pam White
2023-03-10
At Hotze Health and Wellness YOU can truly find restoration of your health and vibrant life! You will find the most caring and effective healthcare available! Don't hesitate call them today!!!
Ron Guidry
Ron Guidry
2023-03-08
Doctors are not the final authority in our journey of achieving/maintaining health and wellness but having a good team of doctors in your support and guidance community is not only helpful it is wise and also essential. The team and staff at Hotze Health and Wellness are health professionals that you can trust to help you navigate all the misinformation that may be keeping you separated from your optimal level of health.
Caral Reeves
Caral Reeves
2023-01-17
Hotze Beauty is a first class facility! Extreme level of professionalism , knowledge & genuine care❤️‍🩹
Julie Hryszko
Julie Hryszko
2023-01-12
I’ve been a guest at this facility for 15 years. They are the most efficient, thorough and caring group of individuals I’ve ever experienced. Dr Hotze looks to change the way a typical doctor treats patients and looks for root causes to eliminate medical issues instead of treating “symptoms”. My life has improved 100% since my initial visit. The cost of the treatments are worth it.
Shavon Sisson
Shavon Sisson
2023-01-11
Always a great experience dealing with everyone at Hotze Heath and Wellness! Everyone is kind and helpful.
Kori Misson
Kori Misson
2022-12-21
I cannot accurately describe in words how I feel about this practice and the entire staff. I have had quite a few health issues throughout the years, rheumatoid arthritis, sjogrens, weight gain, hair loss, irritability, and that is just the beginning. I had pretty much given up on feeling good, just decided to "live with it" and hope for the best. Two very close friends love the Hotze Wellness Clinic and they have experienced life changing health. Made my appointment and from the beginning I felt heard. Not a in and out fast food style practice. They are looked and are looking at my entire body for overall health and wellness. Connections from mind and body to clinical blood work, even dental questions....they care and I feel as if I can trust them. I am on a path to complete wellness and my goal is to have my RA back in remission as it once was....make yourself a priority. Having hope is an incredible feeling!